As the bad guys in the Neckbeards-franchise, The Antagonists do what they want, when they want. Consisting of mostly chads, prom queens, and imposter beta males, the group has several advantages over their arch nemeses, The Protagonists. Mainly, they have the physical prowess - and the willingness to use it.

The Antagonists are mostly empathy-deficient for whatever reason and strive to destroy weaker specimen for the sheer fun of it. Also, some members of The Protagonists end up losing their sanity and joining Antagonist ranks, as is the case with the school shooter.